Kentei year 3048, a long time ago from now, or perhaps in the far future –––
A country that can be anywhere and nowhere in this world –––

Endless wars filled the far east land for decades leaving only the dominance of chaos and devastation. Eyes, ears, mouth, arms, hands, legs, feet… warlord Daigo Kagemitsu grieving the age of endless warfare, offered 48 parts of his unborn son’s body to the monsters to seize the dark powers to rule the world of confusion. Missing almost all parts of his body, Daigo’s son Hyakkimaru born after his father’s contract with the devils looked rather like a block of flesh that could hardly be recognized as a human being.

Soon after being abandoned by his mother by Daigo’s orders, Hyakkimaru was adopted and raised by doctor Jukai. Feeling from the baby a strong desire to live, Jukai gave the baby with a manmade body and a cursed sword to guard himself from the attacking monsters.

Years later – learning from Jukai right before his last breath that Hyakkimaru will be able to get back real parts of his body by slaying the monsters, sets out on a lonely monster hunt and destiny brings him top the encounter with Dororo. A man-disguised female thief who was on her journey seeking revenge on her parents’ killer, was immediately attracted to the cursed sword implanted in Hyakkimaru’s left arm and the mysteries of his cursed body. Ally or enemy, not knowing what to become of their lives the next day, Hyakkimaru and Dororo starts to travel together on an unknown journey.

Body taken away for his father’s ambition –––––
Parents taken away for the time’s power ––––––
A vast darkness spreads ahead of the encounter of Hyakkimaru and Dororo.